Circulating MicroRNA Expression Profiles Associated With Systemic Lupus Erythematosus
نویسندگان
چکیده
منابع مشابه
Circulating microRNA expression profiles associated with systemic lupus erythematosus.
OBJECTIVE To evaluate the specificity of expression patterns of cell-free circulating microRNAs (miRNAs) in systemic lupus erythematosus (SLE). METHODS Total RNA was purified from plasma, and 45 different specific, mature miRNAs were determined using quantitative reverse transcription-polymerase chain reaction assays. A total of 409 plasma samples were obtained from 364 different patients wit...
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The discovery of microRNAs (miRNAs) and their critical role in genetic control opened new avenues in understanding of various biological processes including immune cell lineage commitment, differentiation, proliferation and apoptosis. However, a given miRNA may have hundreds of different mRNA targets and a target might be regulated by multiple miRNAs, thus the characterisation of dysregulated m...
متن کاملCirculating interleukin-16 in systemic lupus erythematosus.
OBJECTIVE To investigate the relationship between interleukin (IL)-16 and systemic lupus erythematosus (SLE). METHODS Serum levels of IL-16 were examined in SLE patients using an enzyme-linked immunosorbent assay (ELISA). RESULTS The serum level of IL-16 in the patients was much higher than that in healthy volunteers (P < 0.001). An increase in IL-16 was observed in proportion to the activi...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 2013
ISSN: 0004-3591
DOI: 10.1002/art.37890